Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Learning induces activation-mechanism-dependent neural plasticity in an intracortical microstimulation task.

bioRxiv : the preprint server for biology·2026

Same author

An innovative germination-driven LAB fermentation strategy for allergenicity reduction in soymilk gels through spatiotemporal protease-mediated epitope disruption.

Food & function·2026

Same author

Bioactive Seed Coating with Chitosan-Salicylic Acid Networks Activates Folate Metabolism and Nutritional Fortification in Wheat Seedlings.

Journal of agricultural and food chemistry·2026

Same author

An Immune Model Incorporating NK Cells and IL-12 to Predict the Efficacy of the Initial Treatment Cycle of Efgartigimod in Generalized Myasthenia Gravis.

Drug design, development and therapy·2026

Same author

Correction: Association between Life's Essential 8 and psoriasis in US adults: a cross-sectional study.

Frontiers in medicine·2026

Same author

A novel hemizygous missense variant in the BEND2 gene is associated with nonobstructive azoospermia.

Asian journal of andrology·2026

Same journal

Digital and scalable laser-based fabrication of reusable bismuth telluride thermoelectrics with superior performance and mechanical flexibility.

Npj flexible electronics·2026

Same journal

Soft bionic actuation explains the functional role of whisking in seal whisker sensing.

Npj flexible electronics·2026

Same journal

Programmable somatosensory soft robots.

Npj flexible electronics·2026

Same journal

Multifunctional, energy-autonomous textile sensors enabled by spray-coated two-dimensional heterostructures.

Npj flexible electronics·2026

Same journal

High output power low temperature polysilicon thin-film transistor boost converters for large-area sensor and actuator applications.

Npj flexible electronics·2026

Same journal

A wireless implantable sensory ring for continuous airway stent migration tracking.

Npj flexible electronics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Sep 13, 2025

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks

Published on: March 2, 2015

Towards Precise Synthetic Neural Codes: High-dimensional Stimulation with Flexible Electrodes.

Robin Kim^1,2, Yuxuan Liu^2,3, Jiaao Zhang^1,2

¹Department of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA.

Npj Flexible Electronics

|July 28, 2025

Summary

This summary is machine-generated.

High-dimensional stimulation precisely manipulates neural states for brain-machine interfaces. This approach overcomes current neuromodulation limitations, enabling advanced synthetic neural codes.

More Related Videos

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments

Published on: November 12, 2019

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Related Experiment Videos

Last Updated: Sep 13, 2025

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks

Published on: March 2, 2015

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments

Published on: November 12, 2019

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Area of Science:

Neuroscience
Biomedical Engineering
Computational Neuroscience

Background:

Neural representations are high-dimensional due to spatiotemporally structured neuron activity.
Current neuromodulation lacks precision for complex neural state manipulation.
This limits the development of effective bidirectional brain-machine interfaces.

Purpose of the Study:

Advocate for high-dimensional stimulation as a systematic approach for brain-machine interfaces.
Propose a method to approximate the high dimensionality of natural neural code.
Address the challenge of precise information writing into the central nervous system.

Main Methods:

Outline technological requirements for high-dimensional stimulation (resolution, coverage, safety).
Review recent advances in critical application areas of neuromodulation.
Highlight the role of flexible electrode technology.

Main Results:

High-dimensional stimulation offers a pathway to overcome current neuromodulation precision limitations.
Flexible electrode technology is crucial for enabling precise synthetic neural codes.
Advances in application areas demonstrate the feasibility of the proposed approach.

Conclusions:

High-dimensional stimulation is a promising strategy for advanced brain-machine interfaces.
Meeting technological requirements is key to realizing precise synthetic neural codes.
This approach holds transformative potential for neuroscience and neural engineering.