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Updated: Sep 13, 2025

Electrowetting-based Digital Microfluidics Platform for Automated Enzyme-linked Immunosorbent Assay

Electrowetting-based Digital Microfluidics Platform for Automated Enzyme-linked Immunosorbent Assay

Published on: February 23, 2020

Integrated heating & sensing for PCB EWOD chips on a digital microfluidics cloud platform.

Mosfera A Chowdury¹, Gnanesh Nagesh¹, Eric Hyunsung Cho²

¹Mechanical, Automotive and Materials Engineering, University Windsor, Windsor, ON, N9B 3P4, Canada. jahamed@uwindsor.ca.

|July 28, 2025

Summary

This study introduces an integrated thermal module for digital microfluidics (DMF) devices, enhancing bioassay accuracy. The novel design offers precise temperature control for individual droplets, improving reliability in lab-on-a-chip applications.

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Area of Science:

Microfluidics
Biotechnology
Sensor Technology

Background:

Digital microfluidics (DMF) using electrowetting-on-dielectric (EWOD) enables automated droplet handling.
Existing DMF platforms lack integrated thermal modules, hindering bioassay accuracy and reliability.

Purpose of the Study:

To develop and validate a novel, co-fabricatable thermal management module for PCB-based DMF devices.
To enable precise, individual droplet temperature control for enhanced bioassay performance.

Main Methods:

Design and numerical simulation of a microheater and sensor pair integrated onto a PCB.
Development of a closed-loop control system for real-time temperature regulation.
Experimental evaluation of thermal performance metrics and on-chip glucose assay.

Main Results:

The module demonstrates high temperature accuracy, stability, and rapid response time.
Effective heat localization and minimal crosstalk were achieved.
Successful application in an on-chip glucose assay validates the module's utility.

Conclusions:

The integrated heating-sensing module seamlessly enhances PCB-based DMF chips with minimal cost.
This advancement supports cloud-based platforms, promoting wider adoption of digital microfluidics.