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A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells

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The Raman Map of the Human Cell.

A M Nowakowska¹, A Pieczara^1,2, W Korona^1,3

¹Faculty of Chemistry, Jagiellonian University in Krakow, Gronostajowa 2, Krakow 30-387, Poland.

Analytical Chemistry

|July 28, 2025

Summary

This study introduces a Raman Map of the Cell method for detailed subcellular analysis. It provides a spectral library to identify organelles in endothelial cells using Raman microscopy.

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Area of Science:

Cell Biology
Spectroscopy
Biophysics

Background:

Cellular functions are dictated by subcellular compartments.
Raman microscopy offers submicron resolution for live cell analysis.
Organelle localization and identification are current challenges in cell analysis.

Purpose of the Study:

To develop a reliable method for subcellular analysis using Raman microscopy.
To create a comprehensive library of Raman spectra for prominent cell organelles.
To map the subcellular landscape of endothelial cells.

Main Methods:

Utilized Raman imaging and advanced chemometric techniques.
Focused on endothelial cells for their biomedical relevance.
Localized organelles such as the nucleus, mitochondria, and lipid droplets.

Main Results:

Established a comprehensive library of Raman profiles for cellular organelles.
Identified marker bands for precise organelle identification.
Mapped the subcellular landscape of a single endothelial cell.

Conclusions:

The Raman Map of the Cell provides a novel approach for subcellular analysis.
The established spectral library aids in precise organelle identification.
This method is valuable for real-time cell metabolism and drug mechanism studies.