Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Root coverage using recombinant human fibroblast growth factor-2 treated connective tissue graft: Case studies.

Clinical advances in periodontics·2025

Same author

Minimally Invasive Sinus Augmentation: A Systematic Review.

Clinical implant dentistry and related research·2024

Same journal

Mitigating thermal risk in guided implant surgery: Hollow-guide and alternative designs.

Clinical advances in periodontics·2026

Same journal

Intentional replantation with apical periodontal ligament preservation: A case report.

Clinical advances in periodontics·2026

Same journal

Customized three dimensionally printed palatal stents: A randomized controlled clinical trial.

Clinical advances in periodontics·2026

Same journal

Subperiosteal tunnel assisted graft (STAG) technique: Report of two cases.

Clinical advances in periodontics·2026

Same journal

Digital workflow to assess healing after acellular dermal matrix exposure in root coverage: A case report.

Clinical advances in periodontics·2026

Same journal

Coronally advanced flap-assisted surgically facilitated orthodontics: A technical note.

Clinical advances in periodontics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Sep 13, 2025

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

Root coverage using a microsurfaced acellular dermal matrix: A retrospective case series.

Yu-Chang Wu¹, Guo-Liang Cheng¹, Shaun Rotenberg^1,2

¹Division of Periodontology, College of Dentistry, The Ohio State University, Columbus, Ohio, USA.

Clinical Advances in Periodontics

|July 28, 2025

Summary

This summary is machine-generated.

A novel microsurfaced acellular dermal matrix (mADM) shows promise for treating gingival recession defects, significantly improving root coverage and patient outcomes. Further trials are needed to confirm its long-term efficacy compared to other treatments.

Keywords:

acellular dermis dental esthetics gingival recession plastic surgery wound healing

More Related Videos

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Published on: March 4, 2016

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

Related Experiment Videos

Last Updated: Sep 13, 2025

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Published on: March 4, 2016

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

Area of Science:

Periodontal regeneration and reconstructive surgery.
Biomaterials in dentistry.
Tissue engineering for oral soft tissue defects.

Background:

Acellular dermal matrices (ADMs) are established for root coverage but have limited advancements in clinical outcomes.
This study introduces a novel microsurfaced ADM (mADM) with a textured surface designed to enhance healing and graft integration.
The objective was to evaluate the efficacy of mADM in treating gingival recession defects.

Observation:

Eleven RT1 gingival recession defects in five patients were treated with mADM.
Surgical techniques included modified vestibular incision subperiosteal tunnel access and subperiosteal pouch techniques.
Clinical outcomes were assessed at baseline and 12 months post-treatment.

Findings:

Mean recession depth significantly decreased from 3.64 mm to 0.73 mm after 12 months (p < 0.05).
Keratinized tissue width increased from 2.32 mm to 3.36 mm, maintaining a thick gingival phenotype.
Achieved 80% mean root coverage, with complete coverage in 45.5% of cases, and no graft exposure or complications.

Implications:

Microsurfaced ADM (mADM) presents a viable alternative for treating RT1 gingival recession defects.
The enhanced surface texture of mADM may promote superior graft integration and healing.
Further randomized clinical trials are warranted to compare mADM with existing treatments for long-term efficacy and patient-reported outcomes.