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Sunitinib-eluting thin films for Inhibition of corneal neovascularization

Kunal S Parikh1,2,3,4, Jin Yang1,2,5, Zheng Ding1

  • 1Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.

Drug Delivery and Translational Research
|July 28, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Corneal neovascularizationElectrospinningNanofiberOcular drug deliverySunitinibTyrosine kinase inhibitor

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Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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