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Modelling and sensitivity analysis of neuronal signal transmission under mechanical loading
Romuald Będziński1, Monika Ratajczak1, Jagoda Kurowiak1
11Department of Biomedical Engineering, Institute of Material and Biomedical Engineering, Faculty of Engineering and Technical Sciences, University of Zielona Gora, Zielona Góra, Poland.
Acta of Bioengineering and Biomechanics
|July 28, 2025
Summary
Mathematical models reveal that mechanical pressure can disrupt nerve signal transmission. Pressures above 1.4 kPa can impair neuronal function, affecting nerve impulse conduction and synapse activity, potentially leading to health issues.
Area of Science:
- Neuroscience
- Biophysics
- Computational Biology
Background:
- Studying neuronal structure and signal transmission is challenging due to complex hierarchical interactions.
- Understanding how mechanical, biochemical, and electrochemical factors influence nerve signals is crucial.
Purpose of the Study:
- To develop a mathematical model of neuronal signal transmission.
- To analyze parameter sensitivity concerning mechanical, biochemical, and electrochemical interactions.
- To investigate nerve signal disturbances caused by overloads.
Main Methods:
- Utilized the Hodgkin-Huxley (HH) model for action potential modeling.
- The HH model comprises coupled differential equations for membrane potential and ion channel dynamics.
- Employed the finite difference method for numerical solutions.
Main Results:
- Simulated changes in nerve cell action potentials under electrical stimulation with high ion channel conductivity.
- Demonstrated that ion channels respond to pressure, modulating neuronal membrane permeability.
- Identified pressure as a factor influencing ion channel function.
Conclusions:
- Pressures exceeding 1.4 kPa may disrupt normal nerve cell function and lead to adverse health outcomes.
- Even minor loads (less than 1%) can cause nervous system dysfunction.
- Mechanical pressure can damage nerve cells, impair impulse conduction, and affect synaptic function.
