Related Experiment Video
Updated: Sep 13, 2025

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy
Published on: August 9, 2024
An Orthopedic Perspective on the Management of Spasticity
Mary Lou1, Ashley Knebel1, Jacob Eberson2
1Department of Orthopaedic Surgery, Brown University, Warren Alpert Medical School, Providence, RI.
Abstract:
Neurologic conditions such as brain injuries, cerebral palsy, stroke and multiple sclerosis involve injury of upper motor neurons, which can manifest as spasticity. The resulting hypertonicity and imbalance of forces between muscle groups leads to deformities that impair patient function and can cause significant long-term complications. Symptoms of spasticity can be managed with nonoperative techniques such as physiotherapy, bracing, or medications. Other approaches such as intrathecal baclofen pumps and selective dorsal rhizotomy have also demonstrated efficacy in controlling spasticity. Spasticity that has failed nonoperative management can be treated with orthopedic surgeries that correct deformities by either restoring joint anatomy or re-balancing the forces of spastic muscle groups. Improved mobility and reduced pain after these procedures can help patients with their rehabilitation, function, and independence.
Related Concept Videos
Spasmolytic Agents: Chemical Classification
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also...
Peripheral Artery Disease IV: Nursing Management
Centrally Acting Muscle Relaxants: Therapeutic Uses
Centrally acting drugs are classified into spasmolytic and antispasmodic drugs. Spasmolytic drugs such as baclofen, diazepam, and tizanidine inhibit spinal motor neurons and decrease muscle tone. Spasmolytic drugs are administered for severe and chronic spasms due to multiple sclerosis, cerebral palsy, stroke, and spinal cord and muscle injuries. However,...
Skeletal Muscle Relaxants: Therapeutic Uses

