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Updated: Sep 13, 2025

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
Published on: February 27, 2018
Adverse postoperative outcomes in geriatric population with a history of cognitive impairment or falls undergoing
Aditya Safaya1, Ahsan Zil-E-Ali1, Kristine L So1
1Division of Vascular Surgery, Heart and Vascular Institute, Pennsylvania State Milton S. Hershey Medical Center, Hershey, PA.
Objective:
We assessed the association of preoperative cognitive impairment/dementia (CI/D) and recent fall history with 30-day postoperative outcomes in patients aged greater than 65 years undergoing vascular surgery.
Methods:
The American College of Surgeons National Surgical Quality Improvement Program was queried for vascular surgery patients aged greater than 65 years in 2021, the first year CI/D and fall history were captured. Patients were categorized into two groups: those without CI/D or falls (group I) and those with either or both (group II). Outcomes included 30-day mortality, unplanned return to operating room, nonhome discharge, and length of stay. Multivariable logistic regression was used to identify independent associations, adjusting for demographic and clinical covariates.
Results:
Among 7057 patients, 458 (6.5%) had CI/D or fall history. Compared with group I, group II patients were older (81.7 years vs 74.3 years), more likely to be functionally dependent (34.7% vs 5.4%), and had a greater comorbidity burden. Group II experienced significantly worse outcomes: 30-day mortality (7.4% vs 2.1%), return to operating room (12.0% vs 7.7%), and nonhome discharge (35.6% vs 11.0%) (all P < .001). On adjusted analysis, CI/D or falls were independently associated with increased odds of mortality (adjusted odds ratio [AOR], 2.08; 95% confidence interval [CI], 1.28-3.37), return to operating room (AOR, 1.49; 95% CI, 1.06-2.22), and nonhome discharge (AOR, 2.28; 95% CI, 1.77-2.93). Isolated CI/D was associated with mortality (AOR, 2.26; 95% CI, 1.14-4.51), and falls alone were associated with return to the operating room (AOR, 1.62; 95% CI, 1.04-2.52) and nonhome discharge (AOR, 2.89; 95% CI, 2.09-3.99).
Conclusions:
In geriatric vascular surgery patients, preoperative CI/D and falls are significant, independent predictors of postoperative mortality and morbidity. These readily identifiable clinical features should be incorporated into preoperative risk assessments to improve surgical decision-making and resource allocation.
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