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Updated: Sep 13, 2025

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A Palladium-Catalyzed Cascade Double Annulation Strategy for Modular Access to Dihydrocyclopenta[b]chromenes
Yanan Liu1, Pui Ying Choy2, Qiang Tang1,3
1Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials (State Key Laboratory Cultivation Base), College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, P. R. China.
None:
The cyclopentachromene skeleton is a key structural motif in pharmaceutical and fluorescent materials. We here introduce a Pd-promoted double ring-closure strategy for tackling the modular synthesis of densely functionalized dihydrocyclopenta[b]chromenes, which proceeds simply from two reaction partners with high diversity. This scheme features a reaction sequence beginning with 1,6-conjugate addition of ortho-alkynyl quinone methide, followed by annulation and migratory insertion. This approach is compatible with functional groups, providing a streamlined pathway to access complex five-membered ring-fused chromenes.
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