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Updated: Sep 13, 2025

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Aerosol Jet Printing for Neuroprosthetic Device Development.

Lander De Waele1, Massimo Di Pietro2,3, Stefano Perilli4

  • 1Movement Control and Neuroplasticity Research Group, KU Leuven, Tervuursevest 101, 3001 Leuven, Belgium.

Bioengineering (Basel, Switzerland)
|July 29, 2025
PubMed
Summary
This summary is machine-generated.

Aerosol jet printing (AJP) offers precise fabrication for advanced neuroprosthetic devices. This technology enables the development of sophisticated neural interfaces and intelligent prostheses with enhanced functionality.

Keywords:
additive manufacturingaerosol jet printingbiocompatible materialsneural interfacesneuroprosthetic devices

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Neuroscience

Background:

  • Aerosol jet printing (AJP) is a key technology for fabricating miniaturized and complex structures.
  • Advanced neural interfaces require high accuracy and versatility in device manufacturing.

Purpose of the Study:

  • To review the principles, advantages, and applications of AJP in neuroprosthetic device development.
  • To highlight AJP's potential in creating next-generation neural interfaces and prosthetics.

Main Methods:

  • Exploration of AJP's aerosol generation and deposition mechanisms.
  • Examination of AJP's scalability, substrate compatibility, and material versatility.
  • Discussion of key implementations in neural interfaces, microelectrode arrays, and flexible electronics.

Main Results:

  • AJP facilitates the use of diverse biocompatible materials on various substrates, including flexible and stretchable ones.
  • Successful fabrication of neural interfaces, microelectrode arrays, and integrated flexible electronics using AJP.
  • Identification of challenges including biocompatibility and long-term stability of conductive traces.

Conclusions:

  • AJP is a transformative technology for advancing neuroprosthetic applications.
  • Future directions include sensorized prosthetic limbs, biosensor integration, and intelligent prostheses.
  • AJP shows significant potential for clinical translation and commercialization in neuroprosthetics.