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Plastic Reconstruction of Upper Extremity Defects in Necrotizing Soft Tissue Infections
Karren M Takamura1, Jason J Yoo2
1Department of Orthopaedic Surgery, University of Maryland Shock Trauma, 22 S Greene Street, Baltimore, MD 21201, USA.
Bioengineering (Basel, Switzerland)
|July 29, 2025
Summary
Reconstructing upper extremity necrotizing soft tissue infections (NSTIs) requires careful planning. Various surgical techniques can achieve good functional outcomes for these challenging soft tissue defects.
Area of Science:
- Orthopedics
- Plastic Surgery
- Infectious Diseases
Background:
- Necrotizing soft tissue infections (NSTIs) of the upper extremity present complex reconstructive challenges due to large defects and exposed critical structures.
- Effective management necessitates prompt source control and debridement followed by appropriate soft tissue reconstruction.
Purpose of the Study:
- To review the principles and options for soft tissue reconstruction in patients with upper extremity NSTIs.
- To discuss factors influencing reconstructive method selection and patient outcomes.
Main Methods:
- Review of current literature and established reconstructive techniques for upper extremity soft tissue defects following NSTIs.
- Consideration of patient-specific factors including defect size, exposed structures, comorbidities, and physiological status.
Main Results:
- Soft tissue reconstruction options range from local wound care and dermal substitutes to local, distant pedicled, and free flaps.
- Dermal substitutes can facilitate wound bed preparation for subsequent skin grafting.
- The choice of reconstruction depends on defect characteristics and patient condition.
Conclusions:
- Successful soft tissue reconstruction following upper extremity NSTIs is achievable with various surgical modalities.
- Patient-specific factors are crucial in selecting the optimal reconstructive approach.
- Good functional outcomes can be expected after appropriate reconstruction.

