Systemic Inflammation Index (SII) as a Predictor of Mortality in Intensive Care Units

Area of Science:

• Critical Care Medicine
• Inflammation Biomarkers
• Clinical Pathology

Background:

• Systemic Inflammation Index (SII) is linked to adverse outcomes and inflammation.
• Previous studies show SII efficacy in diverse patient groups.
• This study investigates admission SII and 28-day mortality in ICUs.

Purpose of the Study:

• To assess the correlation between admission Systemic Inflammation Index (SII) and 28-day mortality in intensive care unit (ICU) patients.
• To determine if SII is an independent predictor of mortality in this population.

Main Methods:

• Retrospective cohort analysis of 702 patients in a tertiary ICU.
• Collected demographic, clinical, and laboratory data.
• Calculated SII, NLR, and PLR at ICU admission.

Main Results:

• Overall 28-day mortality was 36.9%.
• Admission SII was significantly higher in non-survivors (p=0.010).
• SII/1000 independently predicted elevated mortality risk (OR 1.029, p=0.042).

Conclusions:

• Admission Systemic Inflammation Index (SII) is crucial for identifying mortality risk in ICUs.
• SII is a significant and independent predictor of mortality.
• Further large-scale prospective studies are needed to generalize findings and clinical application.