Antioxidants Acteoside and Orientin as Emerging Agents in Synergistic Cancer Therapy: A Focus on Innovative
Jagoda Szkudlarek1,2, Ludwika Piwowarczyk1, Anna Jelińska1
1Chair and Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, 3 Rokietnicka, 60-806 Poznań, Poland.
Abstract:
Cancers, particularly those resistant to treatment, stand as one of the most significant challenges in medicine. Frequently, available therapies need to be improved, underscoring the necessity for innovative treatment modalities. Over the years, there has been a resurgence of interest in natural plant substances, which have been traditionally overlooked as anticancer agents. A prime example of this is natural antioxidants, such as acteoside (ACT) and orientin (ORI), which offer novel approaches to cancer treatment, emphasizing liver cancer compared to other cancer types. They reduce oxidative stress by activating the Nrf2/ARE pathway and exhibit anticancer activity, e.g., decreasing Bcl-2 and Bcl-XL expression and increasing Bax levels. This review explores the individual effects of ACT and ORI and their synergistic interactions with sorafenib, temozolomide, 5-fluorouracil (for ACT), celecoxib, and curcumin (for ORI), highlighting their enhanced anticancer efficacy. In addition, ACT and ORI successfully integrate into various drug delivery systems (DDSs), including metal-containing carriers such as nanoparticles (NPs), nanoshells (NSs), quantum dots (QDs), and liposomes as representative examples of lipid-based drug delivery systems (LBDDSs). Advanced methods, including nanotechnology, offer potential solutions to low bioavailability, paving the way for the use of these substances in anticancer therapy.
Insights
Natural antioxidants like acteoside (ACT) and orientin (ORI) show promise against liver cancer. They reduce oxidative stress and enhance chemotherapy efficacy, with nanotechnology improving their delivery.
Area of Science:
- Pharmacology and Toxicology
- Natural Product Chemistry
- Oncology
Background:
- Cancer, especially treatment-resistant forms, poses a major medical challenge.
- There is a growing interest in natural plant-derived compounds as potential anticancer agents.
- Oxidative stress plays a significant role in cancer development and progression.
Purpose of the Study:
- To review the anticancer effects of acteoside (ACT) and orientin (ORI).
- To explore the synergistic interactions of ACT and ORI with conventional chemotherapies.
- To examine the integration of ACT and ORI into advanced drug delivery systems (DDSs).
Main Methods:
- Literature review of studies on ACT and ORI in cancer treatment.
- Analysis of their mechanisms of action, including Nrf2/ARE pathway activation and apoptosis modulation.
- Investigation of their combination with chemotherapeutic drugs (sorafenib, temozolomide, 5-fluorouracil, celecoxib, curcumin) and their incorporation into DDSs (nanoparticles, nanoshells, quantum dots, liposomes).
Main Results:
- ACT and ORI demonstrate anticancer activity by reducing oxidative stress and modulating apoptosis markers (Bcl-2, Bcl-XL, Bax).
- Synergistic anticancer effects were observed when ACT and ORI were combined with specific chemotherapeutic agents.
- ACT and ORI can be effectively incorporated into various nanocarriers and lipid-based drug delivery systems (LBDDSs).
Conclusions:
- ACT and ORI are promising natural antioxidants with significant anticancer potential, particularly for liver cancer.
- Their combination with conventional therapies and advanced DDSs can enhance therapeutic efficacy.
- Nanotechnology-based delivery systems offer solutions to improve the bioavailability of ACT and ORI for anticancer applications.
More Related Videos
Related Concept Videos
02:57Targeted Cancer Therapies
There are several types of targeted therapies against...
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
01:46Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
02:50Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
01:15Drugs that Stabilize Microtubules
01:27Combined Effects of Drugs: Synergism
Such synergistic combinations...