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Cell Carriers for Oncolytic Virus Delivery: Prospects for Systemic Administration
Viktoria A Sarkisova1,2, Alexandra A Dalina1, Daria O Neymysheva1
1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Cancers
|July 29, 2025
Summary
Cell-based carriers offer a promising strategy to improve oncolytic virus (OV) therapy for malignant diseases by enhancing delivery and overcoming immune clearance. This approach utilizes various cell types to shield and target OVs effectively.
Area of Science:
- Oncology
- Virology
- Biotechnology
- Cell Biology
Background:
- Oncolytic viruses (OVs) show promise for treating malignant diseases, with many clinical trials demonstrating safety.
- However, systemic OV administration faces challenges like immune clearance and poor biodistribution.
- Local OV delivery is hindered by limited bioavailability.
Purpose of the Study:
- To review the potential of cell-based carriers for improving oncolytic virus (OV) delivery in cancer therapy.
- To explore various cell types as carriers for shielding and targeting OVs to tumors.
- To analyze the advantages and limitations of different cell carrier strategies.
Main Methods:
- Review of existing literature on cell-based delivery systems for oncolytic viruses.
- Analysis of different cell types, including mesenchymal stem cells (MSCs), neural stem cells (NSCs), immune cells, and cancer cell lines, as potential carriers.
- Evaluation of the feasibility and effectiveness of these cell-based platforms.
Main Results:
- Cell-based carriers can shield oncolytic viruses (OVs) from immune clearance.
- Various cell types, including MSCs and NSCs, have demonstrated feasibility as OV carriers.
- These carriers can improve tumor-targeted delivery and bioavailability of OVs.
Conclusions:
- Cell-based carriers represent a multifaceted tool to enhance oncolytic virus (OV) therapy for malignant diseases.
- Careful selection of cell carrier types, considering their specific properties, is crucial for successful development.
- This approach offers a potential solution to overcome current limitations in OV efficacy and delivery.
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