Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

5.0K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

FOXE1 promotes the progression of pulp inflammation by activating PANoptosis in dental pulp cells.

iScience·2026
Same author

Promoting Effects of Different Organic Acids on the Formation of Transglutaminase-Induced Cross-Linked Soybean Protein Isolate Hydrogels.

Foods (Basel, Switzerland)·2025
Same author

Protective Effects of a Polyherbal Mixture on Intestinal Injury via the NF-κB Signaling Pathway and Gut Microbiota Modulation in Hyperuricemic Mice.

Foods (Basel, Switzerland)·2025
Same author

Roles of Pyroptosis in the Progression of Pulpitis and Apical Periodontitis.

Journal of inflammation research·2025
Same author

Tertiary Lymphoid Structure in Dental Pulp: The Role in Combating Bacterial Infections.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2024
Same author

Melatonin feeding changed the microbial diversity and metabolism of the broiler cecum.

Frontiers in microbiology·2024

Related Experiment Video

Updated: Sep 13, 2025

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate
11:31

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate

Published on: October 31, 2012

16.0K

Craniomaxillofacial-Derived MSCs in Congenital Defect Reconstruction.

Xiaona Song1, Linlin Peng1, Zhuan Bian1

  • 1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.

Biomolecules
|July 29, 2025
PubMed
Summary

Mesenchymal stem cells (MSCs) offer a promising alternative for regenerating tissue defects in craniomaxillofacial congenital anomalies. This review explores their application and challenges for improved clinical outcomes.

Keywords:
congenital defectscraniomaxillofacial-derived MSCsimmunogenicitytissue regeneration

More Related Videos

Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

21.6K
Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model
09:07

Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model

Published on: February 24, 2017

6.8K

Related Experiment Videos

Last Updated: Sep 13, 2025

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate
11:31

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate

Published on: October 31, 2012

16.0K
Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

21.6K
Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model
09:07

Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model

Published on: February 24, 2017

6.8K

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Craniofacial Surgery

Background:

  • Craniomaxillofacial congenital anomalies cause significant physical and psychological distress.
  • Autologous and allogeneic transplantation have limitations for tissue reconstruction.
  • Stem cell-based therapies, particularly mesenchymal stem cells (MSCs), show potential for tissue regeneration.

Purpose of the Study:

  • To review the application of craniomaxillofacial MSCs in treating congenital defects.
  • To identify challenges in the clinical use of MSCs for regenerative therapy.
  • To offer new perspectives for managing these conditions.

Main Methods:

  • Literature review focusing on mesenchymal stem cells (MSCs) in craniomaxillofacial regeneration.
  • Analysis of studies concerning MSCs' proliferative and differentiation capabilities.
  • Examination of clinical challenges including immunogenicity, safety, and efficacy.

Main Results:

  • Mesenchymal stem cells (MSCs) possess high proliferative capacity and multidirectional differentiation potential, making them suitable for tissue regeneration.
  • Existing research highlights the promise of MSCs in addressing tissue defects.
  • Several challenges impede clinical application, including immunogenicity, long-term safety, and therapeutic efficacy.

Conclusions:

  • Craniomaxillofacial MSCs are a viable option for regenerative therapy in congenital defects.
  • Overcoming challenges related to immunogenicity, safety, and efficacy is crucial for clinical translation.
  • Further research is needed to optimize MSC-based treatments for craniomaxillofacial reconstruction.