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[Chronological change in abnormal behavior produced by long-term methamphetamine administration in the rat]
Yakubutsu, Seishin, Kodo = Japanese Journal of Psychopharmacology
|September 1, 1985
Summary
Repeated methamphetamine (MAP) administration in rats showed reduced behavioral effects over time. This suggests MAP-induced psychosis models are better for studying susceptibility than psychosis symptoms.
Area of Science:
- Neuroscience
- Pharmacology
- Animal Models
Context:
- Methamphetamine (MAP) is a psychostimulant drug with potential for abuse.
- Understanding MAP-induced behavioral changes is crucial for developing effective treatments.
- Animal models are used to investigate the neurobiological underpinnings of drug-induced psychosis.
Purpose:
- To investigate the long-term effects of repeated methamphetamine administration on rat behavior.
- To examine changes in MAP-induced abnormal behaviors, including locomotion and stereotypy.
- To assess the relationship between repeated MAP exposure and [3H] spiperone binding sites.
Summary:
- Rats receiving daily methamphetamine injections showed reduced behavioral enhancements over time.
- MAP-induced abnormal behaviors initially increased but later decreased, suggesting tolerance.
- No significant changes in [3H] spiperone binding sites were observed after 100 MAP injections.
Impact:
- Repeated MAP administration in rats may not fully replicate the psychosis symptoms seen in humans.
- This animal model is more valuable for studying the increased susceptibility to MAP-induced psychosis.
- Findings suggest a need for refined animal models to better understand MAP-induced psychosis.