Related Experiment Video
Updated: Sep 13, 2025
07:54
Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
20.0K
Neuro-Ophthalmological Disorders Associated with Obstructive Sleep Apnoea
Snježana Kaštelan1, Lea Kozina2, Maja Alaber3
1Department of Ophthalmology, Clinical Hospital Dubrava, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
International Journal of Molecular Sciences
|July 29, 2025
Summary
Obstructive sleep apnoea (OSA) significantly impacts neuro-ophthalmological health, potentially causing vision loss. Early diagnosis and treatment, like CPAP therapy, are crucial for managing these serious complications.
Area of Science:
- Ophthalmology
- Neurology
- Sleep Medicine
Background:
- Obstructive sleep apnoea (OSA) involves airway obstruction during sleep, leading to hypoxia and fragmented sleep.
- Emerging evidence links OSA to neuro-ophthalmological conditions like glaucoma, optic neuropathy, and visual field defects.
Purpose of the Study:
- To explore the mechanisms connecting OSA to neuro-ophthalmological disorders.
- To review diagnostic tools and management strategies for OSA-related neuro-ophthalmological complications.
Main Methods:
- Review of pathophysiological pathways (hypoxia, oxidative stress, inflammation, intracranial pressure).
- Discussion of diagnostic tools (OCT, polysomnography).
- Analysis of management strategies (CPAP, surgery, lifestyle modifications).
Main Results:
- Hypoxia, oxidative stress, inflammation, and intracranial pressure fluctuations contribute to ocular and neurological impairments in OSA.
- Advanced diagnostics can detect subclinical changes, enabling timely intervention.
- CPAP therapy shows efficacy in mitigating complications, alongside other interventions.
Conclusions:
- Recognizing and treating neuro-ophthalmological disorders in OSA patients is vital for preventing irreversible damage.
- Further research is needed on long-term treatment impacts and biomarkers.
- A multidisciplinary approach is essential for comprehensive care.
Keywords:
glaucomaintermittent hypoxiaintracranial pressuremolecular mechanismsneuro-ophthalmologyobstructive sleep apnoeaoptic nerveoxidative stressretinal changesvisual functionMore Related Videos
Related Concept Videos
01:21Sleep Apnea
221
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
221
01:24Sleep-Wake Cycles
1.6K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.6K
01:22Photoreceptors and Visual Pathways
6.5K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.5K
01:17Other Pulmonary Disorders
913
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
913
01:07Narcolepsy
198
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
198
01:17Accessory Structures of the Eye
1.9K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
1.9K