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Updated: Sep 13, 2025

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
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Genetic Susceptibility in Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease: A Case-Control Study

Ioulia Mavrikou1, Marta Castelli2, Tasoula Touloumenidou1

  • 1Hematology & BMT Unit, General Hospital "George Papanikolaou", 57010 Thessaloniki, Greece.

International Journal of Molecular Sciences
|July 29, 2025
PubMed
Summary

Genetic variants in hematopoietic cell transplantation (HCT) complications like Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease (SOS/VOD) were studied. Distinct genetic differences were found between SOS/VOD and transplant-associated thrombotic microangiopathy (TA-TMA), suggesting different disease pathways.

Keywords:
allogeneic hematopoietic stem cell transplantationcomplementdefibrotidegenetic susceptibilitynext-generation sequencingsinusoidal obstruction syndrome (SOS)veno-occlusive disease (VOD)

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