Transcription factor Mohawk regulates tendon/ligament development: A narrative review

Area of Science:

• Biomedical Engineering
• Molecular Biology
• Orthopedics

Background:

• Tendon and ligament injuries are common, causing pain and limited motion due to poor regeneration.
• Mohawk (Mkx) is a key transcription factor in tendon/ligament development.
• Mkx deficiency leads to defects, affecting gene expression and cellular behavior.

Purpose of the Study:

• Investigate molecular mechanisms regulating tendon/ligament development and repair.
• Explore therapeutic approaches for tendon and ligament injuries.
• Deepen understanding of Mkx's role in pathological processes.

Main Methods:

• Conducted a narrative review of 119 studies from PubMed.
• Focused on Mkx and its related genes in tendon/ligament development and repair.
• Examined studies involving mesenchymal stem cells and tendon stem/progenitor cells.

Main Results:

• Mkx is vital for tendon and ligament development.
• Mkx influences gene expression and cellular responses.
• Studies highlight Mkx's role in pathological processes and tissue repair.

Conclusions:

• Mkx is essential for tendon/ligament development and pathology.
• Mkx-related molecular networks are promising for therapeutic strategies.
• Combining Mkx research with stem cells and 3D systems may advance treatment for tendon/ligament diseases.