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Updated: Sep 13, 2025

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
Prognostic value of a simple distance index derived from PET maximum intensity projection
Isaac Kargar Samani1,2, Olivier Gheysens2, Maxime Regnier3
1Department of Nuclear Medicine, CHU UCL Namur, Godinne Site, UCLouvain, Namur, Belgium.
Introduction:
Dissemination indices derived from [18F]FDG PET/CT, such as Dmax, Dmaxbulk, SPREADbulk, SPREADpatient, and DmaxVox are validated prognostic biomarkers in diffuse large B-cell lymphoma. We introduce DmaxVoxMIP, the distance between the outermost voxels of the two most distant lesions on a 2D maximum intensity projection image, which is easy and straightforward to obtain. Our goal is to evaluate DmaxVoxMIP's prognostic value compared to other features for easier clinical application.
Methods:
Metabolic tumor volume and dissemination indices were obtained from LIFEx, while DmaxVoxMIP was obtained from Telemis and OsiriX.
Results:
DmaxVoxMIP was not significantly higher in deceased than in living patients. However, patients with DmaxVoxMIP values above the derived cutoff showed a shorter survival. By combining MTV and DmaxVoxMIP, we obtained 3 risk groups for OS and PFS.
Discussion:
DmaxVoxMIP could advantageously replace other dissemination parameters as a prognostic index in patients with DLBCL.
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