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Hypoglycaemic coma in severe primary hypothyroidism.

K Hermansen, L G Johannsen, O B Rasmussen

    Acta Medica Scandinavica
    |January 1, 1985
    PubMed
    Summary
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    Severe primary hypothyroidism can cause life-threatening hypoglycemia, leading to coma. Prompt glucose treatment and thyroid hormone replacement therapy are crucial for recovery and preventing further hypoglycemic episodes.

    Area of Science:

    • Endocrinology
    • Metabolic Disorders

    Background:

    • Hypoglycemia, a condition of low blood glucose, can present with severe neurological symptoms.
    • Primary hypothyroidism is a common endocrine disorder affecting metabolism.

    Observation:

    • A 76-year-old female presented in a comatose state with critically low blood glucose (1.7 mM).
    • Intravenous glucose administration rapidly restored consciousness.
    • Subsequent diagnosis revealed severe primary hypothyroidism as the underlying cause.

    Findings:

    • Thyroid replacement therapy normalized fasting blood glucose levels.
    • The patient experienced no further hypoglycemic episodes after treatment initiation.

    Implications:

    • Hypoglycemia can be a direct and reversible cause of impaired consciousness in severe hypothyroidism.

    Related Experiment Videos

  • This case highlights the importance of considering and treating endocrine disorders in patients with unexplained coma.
  • Timely diagnosis and specific therapy for hypothyroidism are essential to prevent severe metabolic complications.