Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Humoral Immune Responses01:36

Humoral Immune Responses

76.3K
Overview
76.3K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

928
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
928

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-Dimensional Flow Cytometry Identifies Immune Signatures Associated with Septic Shock Severity in Critically Ill Postoperative Patients.

Anaesthesia, critical care & pain medicine·2026
Same author

Integrated immune and endothelial profiling predicts 90-day mortality in postoperative sepsis and septic shock.

EBioMedicine·2026
Same author

FEASIBILITY AND INTERIM SAFETY AND EFFICACY ANALYSIS OF A FAST AUTOMATED PRODUCTION OF PROPHYLACTIC CMV-SPECIFIC CTLs AFTER ALLOGENEIC HSCT.

Transplantation and cellular therapy·2026
Same author

ZMYM3 mutations modulate histone acetylation and cooperate with NOTCH1 mutations in chronic lymphocytic leukemia.

Blood advances·2026
Same author

Benchtop NMR as a clinical tool for acute respiratory illness: metabolic signatures associated with disease severity.

Respiratory research·2026
Same author

Urinary Cells Flow Cytometry in Renal Disease: A Systematic Review of Diagnostic and Prognostic Applications.

Biomedicines·2026

Related Experiment Video

Updated: Sep 13, 2025

Use of an Influenza Antigen Microarray to Measure the Breadth of Serum Antibodies Across Virus Subtypes
08:52

Use of an Influenza Antigen Microarray to Measure the Breadth of Serum Antibodies Across Virus Subtypes

Published on: July 26, 2019

8.2K

Humoral Response Profile in SARS-CoV-2 Infection: Differences across Virus Strains and Influenza.

Carlota Arias-Hidalgo1, Pablo Juanes-Velasco1, Alba Iglesia-Sánchez1

  • 1Department of Medicine and General Cytometry Service-Nucleus, CIBERONC CB16/12/00400, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), IBSAL, Universidad de Salamanca-CSIC, Campus Miguel de Unamuno, s/n, Salamanca 37007, Spain.

Journal of Proteome Research
|July 29, 2025
PubMed
Summary

COVID-19 patients show distinct autoantibody profiles compared to Influenza A, with SARS-CoV-2 triggering unique immune responses. These findings aid in understanding viral infections and developing targeted treatments.

Keywords:
Influenza A virusSARS-CoV-2 infectionacute-phase reactantsautoantibodiesfunctional proteomicshumoral immune response

More Related Videos

A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies
04:47

A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies

Published on: February 23, 2018

7.8K
An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers
06:34

An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers

Published on: December 1, 2017

36.5K

Related Experiment Videos

Last Updated: Sep 13, 2025

Use of an Influenza Antigen Microarray to Measure the Breadth of Serum Antibodies Across Virus Subtypes
08:52

Use of an Influenza Antigen Microarray to Measure the Breadth of Serum Antibodies Across Virus Subtypes

Published on: July 26, 2019

8.2K
A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies
04:47

A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies

Published on: February 23, 2018

7.8K
An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers
06:34

An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers

Published on: December 1, 2017

36.5K

Area of Science:

  • Immunology
  • Virology
  • Pathophysiology

Background:

  • COVID-19 presents diverse clinical symptoms, complicating diagnosis and treatment.
  • Understanding the humoral immune response is crucial for managing viral respiratory infections.
  • Distinguishing COVID-19 from Influenza A requires detailed immunological profiling.

Purpose of the Study:

  • To compare autoantibody and acute-phase reactant profiles in patients with SARS-CoV-2 and Influenza A.
  • To investigate the humoral immune response to different SARS-CoV-2 strains.
  • To identify factors influencing COVID-19's varied disease presentation.

Main Methods:

  • Utilized customized protein microarrays for analyzing autoantibodies and acute-phase reactants.
  • Compared serological profiles between COVID-19 and Influenza A patient cohorts.
  • Applied multiomics factor analysis to identify key disease drivers.

Main Results:

  • SARS-CoV-2 patients exhibited significantly higher autoantibodies (e.g., against calcitonin-related polypeptides, hepatocyte growth factor, interleukin 8) than Influenza A patients.
  • Influenza A patients showed elevated levels of selectin E and surfactant protein D.
  • Most acute-phase reactants were elevated in SARS-CoV-2 patients; serological analysis revealed distinct IgM/IgG responses to SARS-CoV-2 strains.

Conclusions:

  • Distinct autoantibody profiles differentiate SARS-CoV-2 from Influenza A infections.
  • Humoral immune responses vary based on SARS-CoV-2 strain and infection stage.
  • Insights support the development of novel vaccines and therapeutics for SARS-CoV-2.