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Synthesis and Characterization of Oxazolone-Based Cationic Surfactants: Aggregation Behavior, Surface Properties, and
Salahudheen Vp1,2, Jamsheera Anjudikkal1, Ajmal Koya Pulikkal1
1Department of Chemistry, National Institute of Technology Mizoram, Chaltlang, Aizawl 796012, India.
Langmuir : the ACS Journal of Surfaces and Colloids
|July 29, 2025
Summary
Novel oxazolone-derived cationic surfactants were synthesized and characterized. These compounds exhibit promising self-assembly properties and significant antimicrobial activity against various pathogens.
Area of Science:
- Organic Chemistry
- Materials Science
- Biochemistry
Background:
- Cationic surfactants are crucial in various applications, including antimicrobial formulations.
- Oxazolone derivatives offer a versatile scaffold for designing novel functional molecules.
Purpose of the Study:
- To synthesize and characterize novel oxazolone-derived cationic surfactants.
- To investigate their self-assembly behavior in aqueous media.
- To evaluate their antimicrobial efficacy.
Main Methods:
- Green multicomponent Erlenmeyer-Perkin reaction for synthesis.
- Spectroscopic techniques (FT-IR, HRMS, 1H NMR) for structural confirmation.
- Conductometry, tensiometry, fluorimetry, DLS, and TEM for self-assembly studies.
- Antimicrobial assays against six pathogens.
Main Results:
- Successful synthesis of OXZ-derived cationic surfactants with varying alkyl chain lengths (decyl, dodecyl, hexadecyl).
- Characterization confirmed the structures and revealed self-assembly into micelles.
- Micelle size showed an inverse correlation with alkyl chain length.
- Significant antimicrobial activity was observed against Gram-positive and Gram-negative bacteria and fungi.
Conclusions:
- The synthesized OXZ-derived surfactants are effective surface-active agents with tunable self-assembly properties.
- Their antimicrobial activity makes them potential candidates for new therapeutic or disinfectant agents.
- Hydrophobicity plays a key role in controlling aggregate structure and antimicrobial efficacy.
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