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Related Concept Videos

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Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
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Related Experiment Video

Updated: Sep 13, 2025

Endovascular Perforation Model for Subarachnoid Hemorrhage Combined with Magnetic Resonance Imaging MRI
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Accelerated MRI Sequences for Intracranial Hemorrhage Screening.

James Ryan Loftus, Andrew C McClelland, Kevin Hsu

    Investigative Radiology
    |July 29, 2025
    PubMed
    Summary

    Accelerated MRI sequences (aGRE, aSWI) significantly reduce scan times for amyloid-related imaging abnormalities-hemorrhage (ARIA-H) screening, maintaining diagnostic performance but with some reduction in rater agreement and image quality.

    Keywords:
    Alzheimer diseaseamyloid-related imaging abnormalitiesanti-amyloid-beta immunotherapycerebral microbleedecho-planar imaginggradient-recalled echosuperficial siderosissusceptibility-weighted imaging

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    Area of Science:

    • Neuroimaging
    • Radiology
    • Biomarkers

    Background:

    • Anti-amyloid-beta immunotherapy necessitates frequent MRI screening for ARIA-H (cerebral microbleeds/superficial siderosis).
    • Current MRI sequences (GRE, SWI) are time-consuming, potentially limiting patient enrollment and increasing motion artifacts.
    • Accelerated MRI techniques may improve screening efficiency and patient throughput.

    Purpose of the Study:

    • To evaluate the diagnostic performance of echo-planar imaging (EPI) accelerated GRE (aGRE) and SWI (aSWI) substitutions for detecting CMB and SS.
    • To compare accelerated sequences against standard GRE and SWI in terms of sensitivity, specificity, and predictive values.
    • To assess the impact of acceleration on image quality, motion, and rater agreement.

    Main Methods:

    • Retrospective analysis of 50 patients undergoing FDG PET-3T MRI.
    • Comparison of standard GRE (90s) and SWI (192s) with EPI-accelerated aGRE (13s) and aSWI (33s).
    • Independent assessment by three neuroradiologists for CMB and SS detection, image quality, and motion, with calculation of AUC, PPV, NPV, and inter-rater agreement.

    Main Results:

    • Excellent aggregate AUCs for both CMB (0.84-0.94) and SS (0.89-1.00) across all sequences, with no significant differences between standard and accelerated methods.
    • High negative predictive values (96.5%-100%) for both aGRE and aSWI.
    • Mildly reduced inter-rater agreement for accelerated sequences compared to standard, and reduced perceived image quality, though aSWI showed less motion.

    Conclusions:

    • EPI-accelerated aGRE and aSWI sequences offer substantial time savings (86% and 83%) for ARIA-H screening.
    • These accelerated sequences demonstrate comparable diagnostic performance to standard GRE and SWI for detecting CMB and SS.
    • While accelerated sequences reduce rater agreement and perceived image quality, they represent a viable option for efficient ARIA-H screening.