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Updated: Sep 13, 2025

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
[Chronic coronary syndrome-Update]
Miroslava Valentová1,2, Torben Lange3,4, Birte Viehmeister5
1Klinik für Geriatrie, Universitätsmedizin Göttingen, Robert-Koch-Str. 42, 37099, Göttingen, Deutschland. miroslava.valentova@med.uni-goettingen.de.
Insights
Coronary artery disease (CAD) encompasses chronic and acute conditions, impacting older adults significantly. Early diagnosis and risk factor management are crucial for improving quality of life and prognosis.
Area of Science:
- Cardiology
- Internal Medicine
Background:
- Coronary artery disease (CAD) represents a spectrum from chronic (CCS) to acute coronary syndrome (ACS).
- CAD is a primary cause of mortality in elderly populations.
- Symptoms like angina, dyspnea, and fatigue significantly diminish patients' quality of life.
Purpose of the Study:
- To outline the diagnostic and therapeutic strategies for coronary artery disease.
- To emphasize the importance of risk factor optimization in CAD management.
Main Methods:
- Basic diagnostics include patient history, physical examination, ECG, lab tests, and echocardiography.
- Advanced functional tests include stress MRI, stress echocardiography, and myocardial scintigraphy.
- Direct imaging modalities comprise coronary CT and invasive coronary angiography.
Main Results:
- Treatment decisions are guided by symptom severity, patient preferences, and procedural risks.
- Risk factor optimization and antithrombotic/antianginal therapy form the cornerstone of basic treatment for all ages.
- Revascularization is indicated for patients with refractory symptoms or high-risk profiles.
Conclusions:
- Comprehensive diagnostic approaches are available for CAD, ranging from basic to advanced imaging techniques.
- Risk factor management and guideline-directed medical therapy are fundamental for all CAD patients.
- Revascularization strategies should be carefully considered based on individual patient factors and risk stratification.
Abstract:
Coronary artery disease (CAD) is a continuum between chronic (CCS) and acute coronary syndrome (ACS). It is the leading cause of death in older people. In addition to the prognostic relevance, angina pectoris, dyspnea or fatigue lead to impaired quality of life. The basic diagnostics include anamnesis, physical examination, 12-lead electrocardiography (ECG), laboratory diagnostics and transthoracic echocardiography. Functional investigations, such as stress magnetic resonance imaging (MRI), stress echocardiography, myocardial scintigraphy and direct imaging techniques, such as coronary computed tomography (CT) and invasive coronary angiography are available. The treatment depends on the severity of the symptoms, the patient's wishes and the risk of the procedure. Regardless of age, the basic treatment is strict optimization of risk factors, antithrombotic antianginal therapy. Revascularization is reserved for patients with refractory symptoms or a high-risk constellation.
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