Sprayable zwitterionic self-assembling powder for postoperative adhesion prevention.
Jiayao Wen1, Susu Huang2, Wei He1
1Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Summary
This study introduces a new sprayable hydrogel powder that self-assembles to prevent postoperative adhesions. This innovative drug delivery system utilizes dual anti-inflammatory and antioxidant mechanisms for superior anti-adhesion efficacy.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Drug Delivery Systems
Background:
- Postoperative adhesions are a common surgical complication with significant adverse outcomes.
- Existing treatments and physical barriers for adhesion prevention have limitations.
- Novel drug delivery systems are needed to overcome these limitations.
Purpose of the Study:
- To develop a novel sprayable powder-based drug delivery system for preventing postoperative adhesions.
- To create a self-assembling hydrogel using polysulfobetaine (pSB) and hydroxypropyl-β-cyclodextrin (HCP) nanogels.
- To evaluate the anti-adhesion efficacy and underlying mechanisms of the developed hydrogel system.
Main Methods:
- Development of a sprayable powder system forming zwitterionic hydrogels via electrostatic interactions.
- Loading curcumin into HCP nanogels for sustained release and hydrogel reinforcement.
- In vivo evaluation using a rat abdominal wall-caecum injury model.
- Genomic analysis to elucidate anti-adhesion mechanisms.
Main Results:
- The developed hydrogel powder self-assembles into dynamically cross-linked zwitterionic hydrogels.
- HCP@Cur nanogels ensure prolonged curcumin release, enhancing therapeutic effects.
- Superior anti-adhesive performance observed in vivo compared to commercial HA hydrogel.
- Dual anti-inflammatory and antioxidant actions identified as primary mechanisms.
Conclusions:
- The novel sprayable hydrogel powder demonstrates significant potential for preventing postoperative adhesions.
- The system combines a physical barrier effect with sustained drug release.
- The dual anti-inflammatory and antioxidant mechanisms contribute to its high efficacy, suggesting clinical applicability.
