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Related Experiment Videos

Lower respiratory tract infection.

S M Finegold, C C Johnson

    The American Journal of Medicine
    |November 29, 1985
    PubMed
    Summary
    This summary is machine-generated.

    This study investigated ticarcillin plus clavulanic acid for lower respiratory infections, finding it effective against various bacterial pathogens, including resistant strains. Most patients experienced cures or improvement with minimal side effects.

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    Area of Science:

    • Infectious Diseases
    • Microbiology
    • Pharmacology

    Background:

    • Pneumonia is a leading cause of death, with etiologic diagnosis often challenging.
    • Bacterial resistance to antimicrobials complicates treatment of lower respiratory infections.
    • Empyema and purulent tracheobronchitis also present significant management issues.

    Purpose of the Study:

    • To evaluate the efficacy and safety of ticarcillin plus clavulanic acid in treating patients with pneumonia, empyema, and purulent tracheobronchitis.
    • To identify the spectrum of microorganisms causing these infections and assess their susceptibility to the study drug.

    Main Methods:

    • A clinical study involving nine patients with lower respiratory tract infections.
    • Collection and analysis of clinical samples (pleural fluid, sputum, aspirates) for microbial identification.

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  • Treatment with ticarcillin plus clavulanic acid and monitoring of patient outcomes and adverse effects.

    • Main Results:

    • Ticarcillin plus clavulanic acid demonstrated efficacy in treating pneumonia, empyema, and purulent tracheobronchitis.
    • A diverse range of bacteria, including anaerobes, Streptococcus pneumoniae, Staphylococcus aureus, and gram-negative bacilli, were identified.
    • Eight patients achieved cure, and one showed improvement, with only minor side effects reported.

    Conclusions:

    • Ticarcillin plus clavulanic acid is an effective therapeutic option for various lower respiratory tract infections caused by a broad spectrum of bacteria.
    • The drug exhibited a favorable safety profile, with minimal adverse events observed.
    • Effective management of these infections requires accurate etiologic diagnosis and appropriate antimicrobial therapy.