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Updated: Sep 13, 2025

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In Situ Targeting RGD-Modified Cyclodextrin Inclusion Complex/Hydrogel Hybrid System for Enhanced Glioblastoma

Xiaofeng Yuan1,2,3, Zhenhua Wang3, Pengcheng Qiu2

  • 1Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.

Pharmaceutics
|July 30, 2025
PubMed
Summary
This summary is machine-generated.

A novel hydrogel system loaded with doxorubicin (DOX) and RGD-conjugated cyclodextrin (RGD-CD) effectively targets glioblastoma (GBM). This targeted drug delivery system enhances anti-cancer efficacy and improves survival rates in GBM models.

Keywords:
cyclodextrindoxorubicinglioblastomahydrogelinclusion complex

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis.
  • Innovative therapeutic strategies are crucial for effective GBM treatment.
  • Current treatments face challenges in drug delivery and efficacy.

Purpose of the Study:

  • To develop and evaluate a novel in situ targeting inclusion complex hydrogel hybrid system (DOX/RGD-CD@Gel) for enhanced GBM therapy.
  • To integrate doxorubicin (DOX) with RGD-conjugated cyclodextrin (RGD-CD) within a thermosensitive hydrogel.
  • To assess the drug delivery and antitumor efficacy of the developed system.

Main Methods:

  • Preparation of the DOX/RGD-CD@Gel system by conjugating DOX with RGD-modified cyclodextrin and embedding into a thermosensitive hydrogel.
  • In vitro and in vivo evaluation of drug delivery and antitumor efficacy.
  • Assessment of cytotoxicity, apoptosis promotion, cell proliferation and metastasis inhibition.

Main Results:

  • DOX/RGD-CD@Gel demonstrated significantly enhanced cytotoxicity compared to free DOX or DOX/CD formulations.
  • The targeted system effectively promoted apoptosis and inhibited GBM cell proliferation and metastasis.
  • In vivo studies in a GBM mouse model showed suppressed tumor growth and improved survival rates.

Conclusions:

  • The study presents a novel targeted inclusion complex hydrogel hybrid system for localized GBM therapy.
  • This integrated approach offers a safe and efficacious strategy with potential translational value.
  • The system shows promise for improving outcomes in glioblastoma treatment.