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Recent Research Advances in HER2-Positive Breast Cancer Concerning Targeted Therapy Drugs

Junmin Li1, Xue Li2, Ruixin Fu1

  • 1School of Biology and Food Science, Shangqiu Normal University, Shangqiu 476000, China.

Molecules (Basel, Switzerland)
|July 30, 2025
PubMed

Insights

Targeted therapy drugs for HER2-positive breast cancer, including monoclonal antibodies and tyrosine kinase inhibitors, offer improved treatment options. This review categorizes these advancements and discusses their efficacy and challenges.

Area of Science:

  • Oncology
  • Pharmacology
  • Biotechnology

Background:

  • Breast cancer is a prevalent malignancy affecting women globally.
  • HER2-positive breast cancer represents an aggressive subtype with a poor prognosis, necessitating targeted therapies.
  • Targeted therapies against HER2 are crucial for managing this specific breast cancer subtype.

Purpose of the Study:

  • To review and categorize the advancements in HER2-targeted drugs for breast cancer.
  • To provide a comprehensive overview of approved drugs and ongoing clinical trials.
  • To offer references for developing precise treatment strategies for HER2-positive breast cancer.

Main Methods:

  • Categorization of HER2-targeted drugs based on their mechanism of action.
  • Focus on approved drugs and clinical trial data.
  • Analysis of drug indication, administration, efficacy, strengths, and challenges.

Main Results:

  • HER2-targeted drugs are classified into four main types: monoclonal antibodies (mAbs), tyrosine kinase inhibitors (TKIs), antibody-drug conjugates (ADCs), and bispecific antibodies (bsAbs).
  • Significant progress has been made in drug target discovery, compound screening, and antibody modification.
  • These advancements provide diverse therapeutic options and improved benefits for individual patients.

Conclusions:

  • HER2-targeted therapies have significantly advanced, offering better outcomes for HER2-positive breast cancer patients.
  • Continued research and development in this area are vital for refining treatment strategies.
  • This review serves as a valuable resource for clinicians and researchers in HER2-positive breast cancer treatment.
Keywords:
antibody-drug conjugates (ADCs)bispecific antibodies (bsAbs)breast cancerhuman epidermal growth factor receptor 2 (HER2)monoclonal antibodies (mAbs)targeted therapy drugstyrosine kinase inhibitors (TKIs)

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