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Updated: Sep 13, 2025

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A novel experience with remission of severe, recalcitrant fontan-associated protein-losing enteropathy: a case report
Kaitlin R Tindel1, Matthew Lemler2, Sonali S Patel2
1Department of Pharmacy, Dallas Children's Medical Center, Dallas, TX, USA.
Abstract:
Protein-losing enteropathy associated with failing Fontan circulation remains a significant challenge in long-term, single-ventricle circulation management. Evidence is very limited regarding medical therapies associated with a reduction in disease severity and morbidity outside of cardiac transplantation. We report a novel experience with remission of recalcitrant protein-losing enteropathy after treatment of Cryptosporidium gastroenteritis with a combination of antimicrobials including nitazoxanide, paromomycin, and azithromycin.
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