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Related Concept Videos

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Overview of Algae

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The kingdom Archaeplastida encompasses red and green algae, along with land plants. Unlike other protists with chloroplasts that arose through secondary endosymbiosis, only red and green algae originated from primary endosymbiotic events. This diverse group of eukaryotic organisms contains chlorophyll and performs oxygenic photosynthesis.Algae exist in various forms, from large brown kelp in coastal waters to green scum in puddles and stains on rocks or soil. Some species are responsible for...
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Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
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Related Experiment Video

Updated: Sep 13, 2025

High-Throughput Metabolic Profiling for Model Refinements of Microalgae
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Decoding the Molecular Mechanism of Bioactive Compounds Derived from Microalgae via Transcriptomics Data and

Hina Shahid1, Muhammad Ibrahim2, Wadi B Alonazi3

  • 1MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, Liaoning, China.

Current Computer-Aided Drug Design
|July 30, 2025
PubMed
Summary
This summary is machine-generated.

This study uses bioinformatics to find molecular targets in microalgae compounds for immune and metabolic diseases. Key genes identified could be repurposed for drug development, offering new therapeutic avenues.

Keywords:
C. karianus.GEO2RGOKEGGMicroalgaeP. reticulatum

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Area of Science:

  • Bioinformatics
  • Molecular Biology
  • Pharmacology

Background:

  • Microalgae are sustainable sources of bioactive compounds with potential applications in various industries.
  • Understanding the molecular mechanisms of these compounds is crucial for identifying therapeutic uses.

Purpose of the Study:

  • To elucidate the molecular mechanisms of microalgae-derived bioactive compounds using integrative bioinformatics.
  • To identify potential therapeutic applications, particularly in immune and metabolic diseases.

Main Methods:

  • Utilized gene expression profiles from GEO datasets (GSE113144, GSE115827).
  • Identified differentially expressed genes (DEGs) using GEO2R and constructed a protein-protein interaction (PPI) network.
  • Cross-validated findings using bioinformatics tools, databases, and literature review.

Main Results:

  • Identified 2051 DEGs after oxo-fatty acid treatment and 399 DEGs after sea spray aerosol treatment, with 39 shared genes.
  • Discovered ten key hub genes (PBK, CENPA, ASPM, DLGAP5, DEPDC1, SPC25, CDCA3, HJURP, ERCC6L, KIF18B) involved in immune and metabolic processes.
  • Highlighted roles in cholesterol/fatty-acyl-CoA binding and identified PBK and CDCA3 as druggable targets.

Conclusions:

  • Enriched molecular functions suggest pharmacologically actionable pathways for diseases like NAFLD and chronic inflammation.
  • Identified druggable hub genes and immune-metabolic functions provide a basis for further research.
  • This study enhances understanding of microalgae's therapeutic potential in drug discovery and nutraceutical development.