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Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Sep 13, 2025

Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate
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Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate

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Retinal Detachment After Primary Congenital Glaucoma Surgery.

Nader Hussein Lotfy Bayoumi, Nada Alaa Eldin Khalifa, Merna Moustafa

    Journal of Pediatric Ophthalmology and Strabismus
    |July 30, 2025
    PubMed
    Summary

    Retinal detachment (RD) occurred in 3.5% of eyes after primary congenital glaucoma (PCG) surgery. Of these, 41% resulted in atrophia bulbi, highlighting a significant complication risk in PCG patients.

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    Area of Science:

    • Ophthalmology
    • Pediatric Ophthalmology
    • Glaucoma Research

    Background:

    • Primary congenital glaucoma (PCG) is a rare, severe form of glaucoma requiring surgical intervention.
    • Retinal detachment (RD) is a known complication following ocular surgery, particularly in eyes with pre-existing conditions.
    • Understanding the incidence and risk factors for RD in PCG patients is crucial for improving surgical outcomes and patient management.

    Purpose of the Study:

    • To determine the incidence of retinal detachment (RD) in eyes that underwent surgery for primary congenital glaucoma (PCG).
    • To identify clinical characteristics and surgical factors associated with RD development in PCG patients.
    • To report on the visual outcomes and management of RD in this cohort.

    Main Methods:

    • A retrospective chart review was conducted at Alexandra Main University Hospital.
    • Data from 363 children (507 eyes) with PCG who had surgery between January 2005 and March 2019 were analyzed.
    • Eyes that developed RD were compared to control eyes regarding demographic, clinical, and surgical characteristics.

    Main Results:

    • Retinal detachment (RD) occurred in 17 eyes (3.35%) of 13 children (3.58%) with primary congenital glaucoma (PCG).
    • No significant differences in intraocular pressure, corneal diameter, axial length, or cup/disk ratio were found at presentation between case and control eyes.
    • Case eyes underwent twice as many glaucoma procedures as control eyes, and a statistically significant difference in axial length was noted at presentation and RD diagnosis (P < .001).
    • At final follow-up, 7 eyes (41.2%) experienced atrophia bulbi.

    Conclusions:

    • Retinal detachment (RD) is a significant complication following primary congenital glaucoma (PCG) surgery, occurring in 3.5% of eyes.
    • Eyes with PCG undergoing surgery have a higher risk of RD, with a substantial proportion leading to atrophia bulbi.
    • Further research into preventative strategies and improved surgical techniques for PCG is warranted to mitigate RD risk.