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Bubble Sweeping Nanomotors for Acute Kidney Injury Therapy
Jiahui Sun1, Weixin Wang1, Rui Gao1
1Department of Pharmacology, School of Pharmacy, Binzhou Medical University, Yantai 264003, P. R. China.
ACS Applied Bio Materials
|July 30, 2025
Summary
This study introduces a novel nanomedicine for acute kidney injury (AKI) treatment. It utilizes platinum and cerium dioxide nanoparticles to reduce oxidative stress, inhibit ferroptosis, and alleviate mechanical stress, protecting kidney tissue.
Area of Science:
- Biomedical Engineering
- Nanomedicine
- Nephrology
Background:
- Acute kidney injury (AKI) involves significant renal ischemic damage, affecting tissue ultrastructure, metabolism, function, and electrophysiology.
- Current treatments for AKI face challenges in addressing the complex microenvironment and multifaceted damage.
Purpose of the Study:
- To develop a precision nanomedicine strategy for protecting kidney tissue against AKI.
- To enhance antioxidative stress, inhibit ferroptosis, and regulate mechanical stress in the AKI microenvironment.
Main Methods:
- Utilized platinum (Pt) and hyaluronic-acid-modified bovine serum albumin nanoparticles loaded with cerium dioxide (CeO2).
- Investigated the catalytic activity of Pt in producing O2 from H2O2 to reduce hypoxia.
- Assessed the role of CeO2 in eliminating reactive oxygen species (ROS) and alleviating ferroptosis and mechanical stress.
Main Results:
- Pt catalyzed H2O2 to O2, reducing cellular hypoxia in the AKI microenvironment.
- CeO2 nanoparticles effectively eliminated ROS and restrained oxygen free radical damage.
- The combined action of CeO2 and O2 alleviated ferroptosis and ameliorated mechanical stress, with O2 facilitating nanoparticle shuttling.
Conclusions:
- The developed nanomedicine system precisely protects against AKI by reducing oxidative damage, downregulating ferroptosis, and ameliorating mechanical stress.
- This system demonstrates potential as an active drug delivery platform for AKI treatment.
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