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Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles

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Stromal reprogramming in solid tumors by nanoparticles: A review.

Farag M A Altalbawy¹, Uday Abdul-Reda Hussein², Suhas Ballal³

¹Department of Chemistry, University College of Duba, University of Tabuk, Tabuk, Saudi Arabia.

Bioorganic Chemistry

|July 30, 2025

Summary

This summary is machine-generated.

Nanoparticles offer precise delivery for tumor stromal reprogramming, a key strategy in cancer treatment. This approach targets tumor stromal cells to overcome therapy resistance and enhance treatment efficacy.

Keywords:

Cancer Immunotherapy Nanoparticles Stromal Reprogramming Tumor Stroma

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Area of Science:

Oncology
Nanotechnology
Biomedical Engineering

Background:

The tumor microenvironment, particularly the stroma, plays a crucial role in tumor progression and resistance to cancer therapies.
Tumor stromal cells are integral to the tumor microenvironment and represent a significant therapeutic target.

Purpose of the Study:

To provide a comprehensive review of nanoparticle applications in tumor stromal reprogramming for cancer treatment.
To explore the current understanding, diverse nanoparticle types, targeting strategies, and therapeutic potential in this rapidly advancing field.

Main Methods:

Review of current literature on nanoparticle-based tumor stromal reprogramming.
Categorization of nanoparticles into organic and inorganic types.
Analysis of passive and active targeting strategies for tumor stromal cells.
Evaluation of preclinical and clinical studies on nanoparticle therapies.

Main Results:

Nanoparticles enable precise delivery of therapeutic agents to tumor stromal cells, facilitating modulation of the tumor microenvironment.
Diverse organic and inorganic nanoparticles have been developed for stromal targeting.
Both passive and active targeting strategies show promise in directing nanoparticles to stromal cells.

Conclusions:

Nanoparticle-based tumor stromal reprogramming presents a novel and promising therapeutic strategy for cancer treatment.
Further research into preclinical and clinical applications is warranted to fully realize the potential of these approaches.