Related Experiment Video
Updated: Sep 13, 2025
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
Visual Field Progression Rates in Glaucoma: Frontloaded Versus Clinical Standard (Nonfrontloaded) SITA-Faster
Jack Phu1, Henrietta Wang2, Katherine Masselos3
1From the School of Optometry and Vision Science, (J.P., H.W., M.K.), University of New South Wales, Kensington, New South Wales, Australia; Centre for Eye Health, (J.P., H.W., K.M., A.A.), University of New South Wales, Kensington, New South Wales, Australia; Faculty of Medicine and Health, (J.P.), University of Sydney, Sydney, New South Wales, Australia; Concord Clinical School, (J.P.), Concord Repatriation General Hospital, Concord, New South Wales, Australia.
Purpose:
To compare glaucoma progression detection rates using mean deviation (MD) slopes when using frontloaded (2 visual field [VF] tests per eye per visit) and clinical standard (1 VF test per eye per visit) 24-2 SITA-Faster test protocols in a clinical practice.
Design:
Prospective accuracy analysis comparing assessment methods.
Subjects:
6571 reliable VF tests of 336 subjects.
Methods:
Mean deviation (MD) slopes were calculated for each eye for each participant over time, with significant slopes (P < .05) defining progression. The number of progressors were compared between frontloaded and clinical standard approaches using the McNemar test. Time and visit to detection and progression rates were compared for mutually detected cases using Wilcoxon rank-sum tests.
Main Outcome Measure:
Cases of progression detected, time and visit to detection, and progression rates.
Results:
The average baseline MD values were -1.94 dB and -1.78 dB for right and left eyes, respectively. Over approximately 2.7-2.8 years of follow-up and 6.2-6.4 visits, there were 25 and 33 unique cases of progression detected for right and left eyes, respectively. Frontloading detected more than 2.3 times more progressors compared with the clinical standard. When considering mutually detected cases, frontloading resulted in an average of 0.5 years' earlier detection compared to the clinical standard (P = .0087). For those who progressed, there was no significant difference in the progression rate measured using either method (P > .05).
Conclusions:
Frontloaded (two 24-2 SITA-Faster VF tests per eye per visit) tests detected more than twice the number of glaucoma progressors based on MD slopes in a cohort of patients with predominantly early glaucoma, compared with the clinical standard (1 VF per eye per visit). These results provide, for the first time, empirical evidence supporting frontloaded VF testing to detect more cases of glaucoma progression at an earlier time point, thereby allowing earlier intervention to minimize vision loss.
More Related Videos
06:25Author Spotlight: Assessment of Visual Acuity in Central Vision Loss Through Motion-Based Peripheral Vision Testing
Published on: February 23, 2024
07:12Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss
Published on: April 11, 2025
Related Concept Videos
01:27Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:25Glaucoma: Overview
01:28Angle Closure Glaucoma: Treatment