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Updated: Sep 13, 2025

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Research progress on blood therapy for anti-aging.

Shuguang Liu1, Shichun Wang1, Yibo Dong1

  • 1Department of Blood Transfusion, First Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, PR China.

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|July 30, 2025
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Blood plays vital roles, but its aging impact is unclear. This review explores blood-based therapies like plasma exchange and platelet factors to combat aging and extend healthspan.

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Area of Science:

  • Gerontology and Hematology
  • Translational Medicine

Background:

  • Blood is essential for oxygen transport, immunity, and more, but its role in aging is understudied.
  • Vascular interventions show promise in decelerating or reversing aging.
  • Existing therapies include heterochronic parabiosis, therapeutic plasma exchange, and platelet-derived treatments.

Purpose of the Study:

  • To clarify the relationship between blood components and biological aging.
  • To guide the development of novel blood therapies for anti-aging applications.
  • To extend healthy lifespan through innovative interventions.

Main Methods:

  • Review of age-related changes in blood factors and cells.
  • Analysis of five blood-targeting anti-aging therapies.
  • Discussion of therapeutic mechanisms, limitations, and future research directions.

Main Results:

  • Identified age-related alterations in circulating blood components.
  • Detailed the anti-aging effects and responsible components of five blood therapies.
  • Explored potential mechanisms underlying these anti-aging effects.

Conclusions:

  • Blood-based therapies offer potential for combating aging.
  • Challenges in clinical translation require further research.
  • Emerging trends point towards innovative blood-derived strategies for longevity.