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Drug-induced Pleuritis Associated with Hachimijiogan
Keisuke Kuroda1, Hirofumi Nakazaki1, Yuri Shibata2
1Department of Respiratory Medicine, Tottori Red Cross Hospital, Japan.
Internal Medicine (Tokyo, Japan)
|July 30, 2025
Summary
A rare case of drug-induced pleuritis was diagnosed in an elderly man after taking hachimijiogan, a traditional Japanese herbal medicine. Discontinuation of the medication led to symptom resolution, highlighting the importance of detailed medication history in diagnosing pleural effusion.
Area of Science:
- Internal Medicine
- Pharmacology
- Pulmonology
Background:
- Pleural effusion diagnosis can be challenging without a clear etiology.
- Drug-induced conditions are an important differential diagnosis for unexplained pleural effusions.
Purpose of the Study:
- To report a rare case of drug-induced pleuritis caused by hachimijiogan.
- To emphasize the significance of a thorough medication history in diagnosing pleural effusions.
Main Methods:
- A case study of a 78-year-old male patient presenting with left-sided pleural effusion.
- Analysis of blood and pleural fluid, medical history review, medication discontinuation, and accidental rechallenge.
Main Results:
- Initial diagnostic tests for pleural effusion were inconclusive.
- Hachimijiogan use was identified as a potential cause.
- Pleural effusion resolved upon discontinuation of hachimijiogan.
- Accidental rechallenge confirmed hachimijiogan as the causative agent for drug-induced pleuritis.
Conclusions:
- Hachimijiogan can cause drug-induced pleuritis, a rare adverse effect.
- Detailed medication history is crucial for diagnosing idiopathic pleural effusions.
- This is the first reported case linking hachimijiogan to drug-induced pleuritis.
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