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Functional substrate-enhanced bioprinting technology for next-generation organ-on-a-chip: from fabrication to
Gihyun Lee1, Soo Jee Kim1, Je-Kyun Park2
1Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.
Trends in Biotechnology
|July 30, 2025
Summary
Advanced substrates enhance bioprinting for tissue engineering, improving organ-on-a-chip models. This integration offers greater precision and functionality for physiologically relevant in vitro systems.
Area of Science:
- Tissue Engineering
- Bioprinting
- Substrate Technology
Background:
- Bioprinting enables microscale biological structure fabrication.
- Substrates are crucial for supporting and enhancing bioprinted constructs.
- Organ-on-a-chip systems require advanced models for physiological relevance.
Purpose of the Study:
- To review how advanced substrates improve bioprinting precision and functionality.
- To explore substrate-enhanced bioprinting for creating advanced in vitro models.
- To highlight the potential for next-generation organ-on-a-chip platforms.
Main Methods:
- Review of recent advances in substrate-enhanced bioprinting.
- Examination of fabrication technologies.
- Analysis of functional applications in tissue engineering.
Main Results:
- Substrates significantly enhance the fabrication precision of bioprinted tissues.
- Enhanced substrates improve the functionality and physiological relevance of engineered tissues.
- Substrate-enhanced bioprinting advances the development of organ-on-a-chip models.
Conclusions:
- Integration of bioprinting and advanced substrates is transformative for tissue engineering.
- This approach bridges the gap between traditional cell culture and complex tissue models.
- It accelerates the development of next-generation organ-on-a-chip platforms.
