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Updated: Sep 13, 2025
Author Spotlight: A Personalized Approach Towards Investigating Alzheimer's Disease Using an In Vitro Blood-Brain Barrier Model
Published on: October 20, 2023
Reconstructing Alzheimer's disease one cell type at a time using in vitro tricultures
Tatiana A Giovannucci1, Charles Arber1, Selina Wray1
1Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, WC1N 1PJ, UK.
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In a recent study, Lish and colleagues used a fully human-based, induced pluripotent stem cell (iPSC)-derived triculture model of neurons, astrocytes, and microglia to delineate non-cell autonomous contributions to familial Alzheimer's disease (AD). This approach offers a versatile platform to explore early disease mechanisms, dissect cell-cell interactions, and support the development of targeted therapeutic or biomarker strategies.
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