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Updated: Sep 13, 2025
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
11.7K
The Link Between Integrins and Oral Diseases
Ersha Liu1, Liujun Zeng1,2,3
1Department of Oral and Maxillofacial Surgery, Centre of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Summary
Integrins are key cell surface proteins involved in oral diseases. This review summarizes their roles in conditions like oral cancer and periodontitis, aiding future research and treatment.
Area of Science:
- Cell Biology
- Oral Medicine
- Biochemistry
Background:
- Integrins are cell surface membrane proteins connecting the extracellular matrix to the cytoskeleton.
- They are crucial in physiological and pathological processes, including tumor development and inflammation.
- Integrins are actively researched in stomatology for their role in oral diseases.
Purpose of the Study:
- To systematically review and synthesize current research on the roles of integrins in various oral diseases.
- To provide a comprehensive summary of integrin involvement in oral biology and disease pathogenesis.
- To reduce research barriers and offer a theoretical basis for preventing and treating oral diseases.
Main Methods:
- A comprehensive literature search was conducted using Web of Science and PubMed databases.
- The review synthesized existing research findings on integrins in oral health and disease.
Main Results:
- Integrins play significant roles in oral squamous cell carcinoma, oral submucous fibrosis, and oral pemphigoid.
- The review covers integrin involvement in oral mucositis, periodontal disease, and peri-implantitis.
- Specific integrins are essential in the pathogenesis of these oral conditions.
Conclusions:
- Integrins are vital in oral disease development and progression.
- Understanding integrin function offers a foundation for novel therapeutic strategies in oral medicine.
- This review consolidates knowledge to advance integrin research and clinical applications in dentistry.
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