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Related Experiment Video

Updated: Sep 13, 2025

Robotic Ablation of Atrial Fibrillation
11:21

Robotic Ablation of Atrial Fibrillation

Published on: May 29, 2015

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Programmable conformal transluminal ablation device for irregular remote small lesions.

Ruizhe Hou1, Hongying Wang1, Jincheng Zou1

  • 1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, P.R. China.

Iscience
|July 31, 2025
PubMed
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A new robotic device offers precise, automated treatment for hard-to-reach atherosclerotic lesions. This multi-channel, multi-level radiofrequency system achieves sub-millimeter accuracy for conformal ablation of irregular targets.

Area of Science:

  • Biomedical Engineering
  • Minimally Invasive Surgery
  • Medical Devices

Background:

  • Micro-surgical advancements enable in vivo access to micro-lesions.
  • Conformal treatment of small, irregularly shaped, or remotely located lesions, particularly atherosclerotic ones, remains a significant challenge.

Purpose of the Study:

  • To develop and validate a programmable conformal transluminal ablation device for automated treatment of irregular remote lesions.
  • To achieve precise, targeted ablation with sub-millimeter accuracy.

Main Methods:

  • Design of a multi-channel and multi-level (MCML) radiofrequency (RF) system integrated with an RF balloon and circulating low-temperature flow.
  • Implementation of a multi-physics-based algorithm for optimizing RF energy delivery to individual electrodes based on target characteristics.
Keywords:
Applied sciencesHealth sciencesNatural sciences

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Last Updated: Sep 13, 2025

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  • Validation using lesion-visible phantoms and ex vivo porcine vessels.

    • Main Results:

    • The developed device successfully performed automated, conformal ablation of irregular lesions with varying shapes and locations.
    • The ablated region closely matched the target lesion boundaries.
    • The system demonstrated sub-millimeter accuracy in energy delivery and lesion targeting.

    Conclusions:

    • The programmable conformal transluminal ablation device offers a viable solution for treating complex atherosclerotic lesions.
    • The system's precision and automation capabilities hold promise for future applications in other transluminal treatments, including lung and bladder cancers.