Predicting neoadjuvant chemoradiotherapy response in rectal cancer: Insights from biomarkers to clinical practice
Hikmet Pehlevan-Özel1, Eda Şahingöz2, Mert Altaş3
1Department of Surgery, Ankara City Hospital, Ankara 06800, Türkiye.
World Journal of Gastrointestinal Surgery
|July 31, 2025
Abstract:
Rectal cancer poses a major global health challenge, with neoadjuvant chemoradiotherapy improving outcomes in locally advanced cases by reducing tumor burden and recurrence risk. However, response variability, including only 15%-20% of patients achieving pathological complete response, underscores the urgent need for accurate predictive tools. This review explored current and emerging biomarkers to enhance neoadjuvant chemoradiotherapy response prediction and inform clinical practice.
Keywords:
BiomarkersClinical predictorsNeoadjuvant chemoradiotherapyPathological complete responseRadiomicsRectal cancerTumor regression grading

