Penile squamous cell carcinoma with posterior urethra involvement: A case report

Penile squamous cell carcinoma (SCC) is a rare malignancy that is more prevalent among immunocompromised individuals. Given that the tumor primarily originates along the penile shaft, it typically affects the anterior urethra. In contrast, primary urethral cancers (PUC) more commonly involve the posterior urethra. The imaging features of penile SCC and PUC often overlap, making the pattern of urethral infiltration a key factor in distinguishing between these 2 conditions. Magnetic resonance imaging (MRI) plays a crucial role in local staging and in identifying the patterns of urethral involvement. We present the case of a 40-year-old man diagnosed with penile SCC following a kidney transplant and prolonged immunosuppressive therapy. This case illustrates the rare occurrence of penile SCC with posterior urethral involvement, as demonstrated through MRI findings. This case sheds light on the possible atypical penile SCC urethral involvement. We aim to highlight its significance for clinicians and radiologists regarding the absence of similar diagnostic imaging illustrations of penile SCC with such a posterior urethra infiltration.