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Single-Flask Manganese(I)-Catalyzed Dienylation and Diels-Alder Cascade: Synthesis of Indole-Cyclohexene Hybrids with

Jinhwan Park1, Da Young Kim2, Yeongmi Park1

  • 1Department of Chemical Engineering (BK21 FOUR Graduate Program), Dong-A University, Busan 49315, South Korea.

Organic Letters
|July 31, 2025
PubMed

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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Generally, the best dienophiles are alkenes containing electron-withdrawing substituents such as carbonyl, nitrile, and nitro groups. The feasibility of a Diels–Alder reaction depends...
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