Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

6.8K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.8K
Tumor Immunotherapy01:27

Tumor Immunotherapy

662
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
662
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

5.0K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

When the World Stopped: A Lesson in Strength and Second Chances.

Oncology (Williston Park, N.Y.)·2026
Same author

Safeguarding Vulnerability: COVID-19's Impact on Immunocompromised Patients With Cancer.

Oncology (Williston Park, N.Y.)·2025
Same author

Artificial Intelligence in Cancer Care: Addressing Challenges and Health Equity.

Oncology (Williston Park, N.Y.)·2025
See all related articles

Related Experiment Video

Updated: Sep 13, 2025

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
11:15

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

10.3K

Immune Modulation in Sarcoma: Targeting the Tumor Microenvironment.

Viviana Cortiana Ms, Jenna Ghazal BSc, Harshitha Vallabhaneni Bs

    Oncology (Williston Park, N.Y.)
    |July 31, 2025
    PubMed
    Summary
    This summary is machine-generated.

    Modifying the sarcoma tumor microenvironment, particularly targeting inhibitory macrophages, is crucial for enhancing cellular therapies like CAR T-cell therapy. This approach aims to improve treatment efficacy and patient survival rates in rare cancers.

    More Related Videos

    Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
    11:42

    Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

    Published on: April 7, 2017

    9.5K
    Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
    07:44

    Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

    Published on: November 28, 2019

    7.6K

    Related Experiment Videos

    Last Updated: Sep 13, 2025

    A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
    11:15

    A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

    Published on: May 6, 2018

    10.3K
    Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
    11:42

    Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

    Published on: April 7, 2017

    9.5K
    Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
    07:44

    Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

    Published on: November 28, 2019

    7.6K

    Area of Science:

    • Immunology
    • Oncology
    • Cancer Therapy

    Background:

    • Sarcomas and rare cancers significantly impact adult health.
    • Current sarcoma treatments require overcoming an inhibitory tumor immune microenvironment.
    • Cellular therapies, including T-cell receptor (TCR), cancer testis antigen (CTA), and chimeric antigen receptor (CAR) T-cell therapy, show promise.

    Purpose of the Study:

    • To investigate the effects of modifying the tumor microenvironment in sarcoma.
    • To understand and enhance the immune response against sarcomas for better treatment outcomes.
    • To explore strategies for overcoming inhibitory macrophages in sarcoma treatment.

    Main Methods:

    • Targeting inhibitory macrophages within the tumor microenvironment.
    • Investigating the optimization of cellular treatment strategies.
    • Exploring the use of interferon gamma and canine CAR T cells.

    Main Results:

    • Altering the tumor microenvironment supports the efficacy of cellular therapy.
    • Strategies targeting inhibitory macrophages can facilitate improved immune responses.
    • Optimized cellular treatments show potential for enhancing patient outcomes.

    Conclusions:

    • Modifying the immune environment is critical for effective sarcoma treatment.
    • Overcoming inhibitory macrophages is key to advancing cellular therapy for sarcomas.
    • New therapeutic approaches involving immune modulation offer revolutionary potential for sarcoma therapy.