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Updated: Sep 13, 2025

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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
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Operationalizing psychological trauma in pregnancy: A systematic review
Helena J V Rutherford1, Kathryn M Wall1, Lindsey Wallace Goldman2
1Yale Child Study Center, Yale University School of Medicine.
Summary
Psychological trauma during pregnancy lacks consistent assessment methods, impacting care. Standardized, early, and ongoing evaluations are crucial for trauma-informed care and well-being.
Area of Science:
- Perinatal mental health
- Trauma studies
- Psychological assessment
Background:
- Psychological trauma during pregnancy has significant health and intergenerational impacts.
- Lack of uniform operationalization of psychological trauma in pregnancy hinders clinical application.
- Standardized assessment is critical for translating research into effective clinical practice.
Purpose of the Study:
- To provide narrative insight into the characterization of psychological trauma during pregnancy.
- To highlight the need for consistent methodologies in assessing trauma in pregnant individuals.
Main Methods:
- Systematic review adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
- Comprehensive literature search across multiple databases (MEDLINE, Embase, Scopus, Web of Science, PsycINFO, Cochrane) from July 2021 to September 2023.
- Dual independent reviewer screening of abstracts, full-text articles, and data extraction.
Main Results:
- 576 studies examined psychological trauma in pregnancy, revealing significant methodological heterogeneity.
- Most assessments (79.7%) used varied questionnaire-based approaches, differing in timing and trauma type.
- Few studies (15.8%) focused on pregnancy-specific trauma, and only 24% offered comprehensive assessment; posttraumatic stress disorder was assessed in 28.8%.
Conclusions:
- Substantial variability exists in how psychological trauma during pregnancy is conceptualized and assessed.
- A need exists for comprehensive, trimester-specific, and repeated assessments of psychological trauma.
- Implementing standardized assessments is vital for trauma-informed care, optimizing maternal and child well-being.
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