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Related Concept Videos

Uterine Tubes01:16

Uterine Tubes

1.1K
The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...
1.1K
Uterus and Cervix01:18

Uterus and Cervix

2.2K
The uterus, commonly called the womb, is a vital reproductive organ in females designed to provide a nurturing environment for the implantation and growth of an embryo. It is shaped like a hollow pear and positioned between the urinary bladder and the rectum. The uterus's structure allows it to support and protect a developing fetus throughout pregnancy.
The uterus is securely anchored within the pelvic cavity by paired broad ligaments on either side. It is further stabilized by three pairs...
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Radiologic response assessment in patients with desmoid-type fibromatosis treated with percutaneous cryoablation.

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Corrigendum to "Management of atypical cartilaginous tumors (ACT): An Italian Sarcoma Group (ISG) consensus document" [Crit. Rev. Oncol. Hematol. 223 (2026) 105358].

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Correction: ASO Visual Abstract: Well‑Differentiated Liposarcoma of the Psoas Muscle: A Distinct Anatomic Subset with Highly Favorable Outcomes.

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Updated pocket guide for integrated risk stratification in endometrial carcinoma: a practical tool based on European Society of Gynecological Oncology/European Society for Radiotherapy and Oncology/European Society of Pathology 2025 guidelines.

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How long is enough? Immunotherapy duration in mismatch repair deficient endometrial cancer.

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In-transit lymph node metastases in the ovarian pedicle in early-stage ovarian cancer: myth or reality?

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Related Experiment Video

Updated: Sep 13, 2025

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
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Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

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Uterine leiomyosarcoma.

Giorgio Bogani1, Giuseppe Caruso2, Isabelle Ray-Coquard3

  • 1Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Department of Surgery, Milan, Italy.

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
|July 31, 2025
PubMed
Summary
This summary is machine-generated.

Uterine leiomyosarcoma is a rare, aggressive cancer. Diagnosis is challenging due to non-specific symptoms and complex patterns, requiring advanced imaging and multidisciplinary care for effective treatment and management.

Keywords:
LeiomyosarcomaSmooth Muscle TumorSoft Tissue SarcomaUterine Sarcoma

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Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells
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Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells
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Area of Science:

  • Gynecologic Oncology
  • Oncology
  • Rare Cancers

Background:

  • Uterine leiomyosarcoma (LMS) is a rare, aggressive gynecological malignancy.
  • Its pathogenesis involves complex genetic aberrations, including TP53 and RB1 alterations.
  • Non-specific clinical presentation and complex imaging/pathology complicate diagnosis.

Purpose of the Study:

  • To review clinical presentation, diagnostic challenges, and evolving therapeutic strategies for uterine LMS.
  • To highlight variations in clinical practice worldwide.
  • To provide an overview of current management based on established guidelines.

Main Methods:

  • Systematic literature review following European Society of Gynaecological Oncology/Gynecologic Cancer InterGroup/European Reference Network on Rare Adult Solid Cancers guidelines.
  • Analysis of diagnostic modalities including advanced imaging (MRI, CT).
  • Evaluation of treatment strategies for different stages and recurrent disease.

Main Results:

  • Early diagnosis is hindered by non-specific symptoms and diagnostic complexities.
  • Treatment varies by FIGO stage, involving surgery, systemic therapy, and radiotherapy.
  • Management of recurrent disease requires a multimodal, individualized approach.

Conclusions:

  • Multidisciplinary management and centralization in referral centers are essential for optimal patient outcomes.
  • Ongoing research into genetic aberrations aims to develop personalized treatment strategies.
  • Standardized yet flexible approaches are needed to address the heterogeneity of uterine LMS.