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Related Experiment Video

Updated: Sep 13, 2025

Polymeric Microneedle Array Fabrication by Photolithography

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

Cleanroom-compatible polymeric nanostructured microneedle patch for advanced wearable applications.

Momina Amir¹, Maria Atalaia Rosa¹, Lina Debeer¹

¹Department of Electrical Engineering (Micro- and Nano Systems), KU Leuven - University of Leuven, Leuven, 3001, Belgium.

Biosensors & Bioelectronics

|July 31, 2025

Summary

This study introduces a novel polymer wearable with microneedles for minimally invasive healthcare. The system demonstrates effective skin penetration and reproducible electrochemical sensing, advancing microneedle diagnostics.

Keywords:

Back-side lithography Cleanroom-compatible technology Nanostructuration Polymeric microneedles Wearable biosensors

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Last Updated: Sep 13, 2025

Polymeric Microneedle Array Fabrication by Photolithography

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Published on: November 17, 2015

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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

Area of Science:

Biomedical Engineering
Materials Science
Nanotechnology

Background:

Microneedles offer minimally invasive drug delivery and biosensing capabilities.
Existing microneedle systems require further development for enhanced functionality and wearability.

Purpose of the Study:

To develop an innovative polymer-based wearable microneedle system.
To integrate SU-8 microneedle arrays with a flexible, stretchable substrate for improved skin conformity.
To enhance sensing capabilities through nanostructured surfaces and versatile configurations.

Main Methods:

Fabrication of 3D microneedles using a single-step backside lithography technique.
Simplified etching process to create nanostructured surfaces on microneedles.
Integration of microneedle arrays onto a flexible, stretchable substrate.
Deposition of metal and dielectric layers for versatile sensing.

Main Results:

Successful fabrication of polymer-based microneedle arrays with nanostructured surfaces.
Demonstrated reproducible performance for hydrogen peroxide electrochemical sensing.
Confirmed successful skin penetration on a skin mimic model, aligning with simulations.

Conclusions:

The developed wearable microneedle system is scalable and cleanroom-compatible.
This technology represents a significant advancement in microneedle-based diagnostics.
The system offers practical and minimally invasive solutions for future healthcare applications.