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Electro-mechanical Systems

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Related Experiment Video

Updated: Sep 13, 2025

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Electro-switchable addressing system for achieving repetitive random data access.

Haotian Yu¹, Yemin Han¹, Weiming Lin¹

¹State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.

Nucleic Acids Research

|July 31, 2025

Summary

This summary is machine-generated.

This study introduces electrical control of DNA conformation for random data access in DNA storage. This method enables efficient information retrieval without damaging the DNA, paving the way for future storage integration.

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Area of Science:

Biotechnology
Data Storage
Molecular Engineering

Background:

DNA data storage offers high density and durability.
Efficient random access is crucial for data retrieval.
Current methods for DNA data access are complex.

Purpose of the Study:

To develop a method for random access to DNA data using electrical actuation.
To enable in situ transcription for multiple reads without DNA damage.
To explore compatibility with future miniaturized storage systems.

Main Methods:

Utilizing electrically driven DNA conformation changes.
Controlling T7 promoter transcription via electrical signals.
Implementing random access on an electrode array chip.

Main Results:

Demonstrated electrical control over DNA conformation to promote or inhibit transcription.
Achieved targeted information access without complex sequence addressing.
Showcased in situ transcription for multiple data reads from a single write event.

Conclusions:

Electrical actuation provides a physical addressing mechanism for DNA data storage.
The developed method allows efficient and non-destructive data retrieval.
This approach supports future integration with DNA synthesis for miniaturized storage solutions.