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Updated: Sep 13, 2025

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Mechanisms of KCNQ1 gating modulation by KCNE1/3 for cell-specific function

Chenxi Cui1, Lu Zhao2, Ali A Kermani3

  • 1Department of Biological Sciences, National University of Singapore, Singapore, Singapore.

Cell Research
|July 31, 2025
PubMed
Summary

KCNE1 and KCNE3 subunits distinctly alter KCNQ1 potassium channel gating. KCNE3 creates a GPCR-regulated, voltage-insensitive channel, while KCNE1 forms a voltage-gated channel crucial for cardiac function.

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